Carmen M. Migdan, Department of Obstetrics and Gynecology, Hospital Universitario Miguel Servet, Zaragoza, Spain
Diego Lerma-Puertas, Department of Perinatal Medicine, Hospital Universitario Clínico, Zaragoza, Spain


Objective: Positive Combined First Trimester Screening and by risk groups: 0-50, 51-100, 101-150, 151-200, 201-250, and normal karyotype relate with negative screening for adverse perinatal results. Method: Retrospective study of cases and controls in single pregnancies, with predictive analysis using multivariate logistic regression. Results: 3,791 screenings were performed at our unit in 2012, with a screening/number of deliveries ratio of 89.9%. There is a greater likelihood of the newborn being underweight (AOR = 2.6, 95% CI 1.2 – 5.7), premature (OR = 2.2, 95% CI 1.03 – 4.5), admitted to the ICU (OR = 7.4, CI 95% 1.5 – 34.6) or admitted to the Neonates department (AOR = 8.1, 95% CI 1.7 – 37.7) in the case group. Conclusion: Combined first trimester screening is a predictive method for pregnant women with a higher risk of adverse perinatal outcomes.



Keywords: PAPP-A. β-HCG. Adverse perinatal outcomes. Aneuploidies.