Sarcoidosis: unusual presentations in a rare entity

Domingo Pérez-Bejarano, Ministry of Public Health and Social Welfare, Hospital General de Luque, Luque, Paraguay

Sarcoidosis is a granulomatous inflammatory disease of unknown etiology that usually affects certain structures such as lungs, skin, eyes, liver, and lymph nodes. Three unusual clinical cases are illustrated and discussed in this paper: Hereford syndrome characterized by fever, anterior uveitis, and salivary gland hypertrophy in its incomplete form; the association of sarcoidosis with thymoma and myasthenia gravis as an expression of an autoimmune complex; and finally, pulmonary hypertension as an epiphenomenon to sarcoidosis, which showed a partial response to immunosuppressants. The reporting of the rare manifestations of this disease is meant to serve as a reminder that symptoms from various systems can come together to form a single diagnostic algorithm, and it also demonstrates the wide range of presentations that can be observed in clinical practice.

Keywords: Sarcoidosis. Heerfordt?s syndrome. Thymoma. Pulmonary hypertension.